Sonographic Comparison of Mean Velocity of Portal Vein in Liver Cirrhosis and Normal Individuals

Journal of Health and Medical Sciences

ISSN 2622-7258

Published: 29 December 2018

Sonographic Comparison of Mean Velocity of Portal Vein in Liver Cirrhosis and Normal Individuals

Nouman Khan, Izhar Hussain, Iftikhar Alam, Raham Bacha, Abdul Rehman, MD Makbul Mikrani, Mehreen Fatima, S. Muhammad Yousaf Farooq, Sajid Shaheen Malik, Syed Amir Gilani

The University of Lahore, Pakistan

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10.31014/aior.1994.01.01.12

Abstract

Background: Liver cirrhosis is a life threatening condition, its consequences ranging from gross financial loss to death. Grayscale ultrasound has been used since long for the diagnosis of liver cirrhosis. Gray scale sonography along with color Doppler is the first-line modality used for evaluating the mean velocity of portal vein in Liver Cirrhosis. Chronic liver parenchymal diseases (CLPD) and liver cirrhosis cause decrease in the flow velocity of portal vein. Doppler ultrasound (US) can determine portal vein (PV) velocity in liver cirrhosis. The mean velocity of portal vein provides a distinguishable value between cirrhotic and normal individuals. Mean portal vein velocity is a reliable parameter in the diagnosis of liver cirrhosis and (CLPD). Objective: To compare mean velocities of portal vein of cirrhotic patients, and normal individuals by Doppler Ultrasound. Methods: A total of 188 individuals were cross-sectionally included in this study. The study was conducted in Gilani Ultrasound Centre, Ferozpur Road, Lahore, while using Toshiba Xario with 3-6 MHz transducer. Results: Mean portal vein velocity in cirrhotic patient was 10.72 ± 1.91 cm/s and in normal individuals was 23.36 ± 6.06 cm/s. Conclusions: Liver cirrhosis causes prominent changes in the texture of liver as compared to the texture in normal individuals. This study showed that mean velocity of portal vein was decreased in patients with liver cirrhosis as compared to normal individuals.

References

  1. AHMAD, W., IJAZ, B., JAVED, F. T., JAHAN, S., SHAHID, I., KHAN, F. M. & HASSAN, S. 2010. HCV genotype distribution and possible transmission risks in Lahore, Pakistan. World journal of gastroenterology: WJG, 16, 4321.

  2. BEDOSSA, P. & CARRAT, F. 2009. Liver biopsy: the best, not the gold standard. Journal of hepatology, 50, 1-3.

  3. CHOUHAN, A., TRIKHA, S., DHAWLE, S., NAGWANSHI, J. & CHANDRA, S. 2015. A study of correlation of esophageal varices in cirrhotic patients with portal haemodynamics with special reference to portal vein diameter, portal vein velocity, congestion index, liver vascular index. Journal of Evolution of Medical and Dental Sciences, 4, 59-67.

  4. ERDOGMUS, B., TAMER, A., BUYUKKAYA, R., YAZICI, B., BUYUKKAYA, A., KORKUT, E., ALCELIK, A. & KORKMAZ, U. 2008. Portal vein hemodynamics in patients with non-alcoholic fatty liver disease. The Tohoku journal of experimental medicine, 215, 89-93.

  5. FRIEDMAN, S. L. 2003. Liver fibrosis–from bench to bedside. Journal of hepatology, 38, 38-53.

  6. GERSTENMAIER, J. & GIBSON, R. 2014. Ultrasound in chronic liver disease. Insights into imaging, 5, 441-455.

  7. HANAFIAH, K. M., GROEGER, J., FLAXMAN, A. D. & WIERSMA, S. T. 2013. Global epidemiology of hepatitis C virus infection: new estimates of age‐specific antibody to HCV seroprevalence. Hepatology, 57, 1333-1342.

  8. HERNAEZ, R., LAZO, M., BONEKAMP, S., KAMEL, I., BRANCATI, F. L., GUALLAR, E. & CLARK, J. M. 2011. Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: a meta‐analysis. Hepatology, 54, 1082-1090.

  9. HERRINE, S. K. & FRIEDMAN, L. S. 2005. Divining the role of liver biopsy in hepatitis C. Journal of hepatology, 43, 374-376.

  10. JEONG, W. K., LIM, H. K., LEE, H.-K., JO, J. M. & KIM, Y. 2014. Principles and clinical application of ultrasound elastography for diffuse liver disease. Ultrasonography, 33, 149.

  11. MARTÍNEZ-NOGUERA, A., MONTSERRAT, E., TORRUBIA, S. & VILLALBA, J. Doppler in hepatic cirrhosis and chronic hepatitis.  Seminars in Ultrasound, CT and MRI, 2002. Elsevier, 19-36.

  12. MEDICINE, A. I. O. U. I. 2003. AIUM Practice Guideline for the performance of an antepartum obstetric ultrasound examination. Journal of ultrasound in medicine: official journal of the American Institute of Ultrasound in Medicine, 22, 1116.

  13. MUKHOPADYAY, I. & SAHA, A. 2015. Quantitative assessment of portal vein by colour Doppler imaging in patients with various liver diseases in West Bengal and reflection of pathophysiological haemodynamics and evaluation of prognosis. Int. J. Recent Scient. Res, 6, 5234-5236.

  14. ORGANIZATION, W. H. 2008. Hepatitis C. Fact Sheet No. 164. Revised October 2000. WHO web site.

  15. PAVLOV, C. S., CASAZZA, G., SEMENISTAIA, M., NIKOLOVA, D., TSOCHATZIS, E., LIUSINA, E., IVASHKIN, V. T. & GLUUD, C. 2016. Ultrasonography for diagnosis of alcoholic cirrhosis in people with alcoholic liver disease. The Cochrane Library.

  16. RIAHINEZHAD, M., REZAEI, M., SANEIAN, H., FAMOURI, F. & FARGHADANI, M. 2018. Doppler assessment of children with liver cirrhosis and portal hypertension in comparison with a healthy control group: An analytical cross-sectional study. Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences, 23.

  17. SAMI, S., KOREJO, R. & BHUTTA, S. Z. 2009. Prevalence of hepatitis B and C: a Jinnah Postgraduate Medical Centre experience. Journal of Obstetrics and Gynaecology Research, 35, 533-538.

  18. SCAGLIONE, S., KLIETHERMES, S., CAO, G., SHOHAM, D., DURAZO, R., LUKE, A. & VOLK, M. L. 2015. The epidemiology of cirrhosis in the United States. Journal of clinical gastroenterology, 49, 690-696.

  19. SHAH, S. M. A., MASHIA, S. A., YOUNUS, M. F., GHAURI, A., EJAZ, R., ALSHALABI, H., KAKAR, I. K. & UMAR, M. 2015. Hepatic cirrhosis-disease burden. J. Rawalpindi Med. Coll. Stud. Suppl, 19, 17-20.

  20. SHEPARD, C. W., FINELLI, L. & ALTER, M. J. 2005. Global epidemiology of hepatitis C virus infection. The Lancet infectious diseases, 5, 558-567.

  21. SIMONOVSKÝ, V. 1999. The diagnosis of cirrhosis by high resolution ultrasound of the liver surface. The British journal of radiology, 72, 29-34.

  22. WONG, J. B., MCQUILLAN, G. M., MCHUTCHISON, J. G. & POYNARD, T. 2000. Estimating future hepatitis C morbidity, mortality, and costs in the United States. American Journal of Public Health, 90, 1562.

  23. WYNN, T. A. & RAMALINGAM, T. R. 2012. Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nature medicine, 18, 1028.

  24. ZHOU, W.-C., ZHANG, Q.-B. & QIAO, L. 2014. Pathogenesis of liver cirrhosis. World journal of gastroenterology: WJG, 20, 7312.

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