Journal of Health and Medical Sciences

ISSN 2622-7258

Published: 04 March 2019

Thyroid Abnormalities Profile of Children Aged 0-1 Years Through Biomarker Examination

Retno Martini Widhyasih, Dewi Inderiati

Ministry of Health Polytechnic Jakarta III

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Thyroid disorder is a non-communicable disease that has the potential to become a public health problem. One endocrinological abnormality that is often found in children is hypothyroidism, which is a condition due to reduced or no production of thyroid hormones. The aim is to evaluate the profile of thyroid abnormalities in children aged 0-1 years at RSAB Harapan Kita by reviewing the results of biomarker examination. Retrospective research design using secondary data at Harapan Kita Hospital Jakarta. The total of medical record was 157 data from January 2015-August 2016. Data analysis of TSH and fT4 biomarker examination results. Diagnosis of thyroid abnormalities can be done by stimulating thyroid hormone (TSH) biomarker examination, free thyroxine (fT4) which is useful as a biomarker for monitoring, detection, or therapy as early as possible in infants or children who are suspected or have experienced growth and development disorders. The study found 51% Euthyroidism, 23% subclinical hypothyroidism, 13% TSH mediated hyperthyroidism condition, 5% secondary hypothyroidism, 4% primary hypothyroidism, and 4% subclinical hyperthyroidism. From medical records, 20.4% were diagnosed with hypothyroidism, 12.7% developmental disorders, 20.1% down syndrome and 40.8% with a diagnosis of other diseases. The diagnosis of thyroid disorder, especially hypothyroidism, is found at 4-12 months of age as much as 22.8% and 8.9% at the age of 0-3 months. These results show that if management or follow-up of treatment and therapy in patients do not do early can cause permanent retardation of growth and mental development. One of the keys to the success of the treatment of children with thyroid disorders is by early detection through laboratory tests and treatment before children are one year old.


  1. Batubara, Jose RL, (2010a). Buku Ajar Endokrinologi Anak Edisi 1. Balai Penerbit UKK Endokrinologi Anak dan Remaja IDAI. Jakarta.. Hal 205-220

  2. Batubara, Jose RL, (2005b). Temu Ilmiah & Simposium Nasional III Penyakit Kelenjar Tiroid. Badan Penerbit Universitas Diponegoro. Semarang. Hal 168

  3. Cebeci, A.N, (2013). Profile of Hypothyroidism in Down Syndrome, J Clin Res Pediatric Endocrinol:5(2) 116-120

  4. Dwi, Ratna S. (2014).Pemeriksaan T3, T4 dan TSH Pada Penderita Hipertiroid. Karya Tulis Ilmiah. Jakarta. Hal 18-21

  5. Hashemipour M, et al, (2009). Permanent and Transient congenital Hypothyroidismin Isfahan Iran, Journal of medical screening, , Vol.16 Number 1. DOI: 10.1258/jms.2009.008090

  6. Ministry of Health RI.( 2015). Situasi dan analisis penyakit tiroid, Pusat data dan informasi Kementrian Kesehatan RI Infodatin.

  7. Permenkes RI No 78. (2014). Skrining Hipotiroid Kongenital. Jakarta. dari (, accessed 10 Januari 2016.

  8. Purnamasari.(2005).Penatalaksanaan Perioperatif Hipotiroid. accesed 05 Februari 2016 (

  9. Purwanti, KD, (2008). Deteksi Dini Hipotiroid Kongenital di Nusa Tenggara Barat, Prosiding pertemuan dan presentasi ilmiah fungsional teknis non peneliti, ISSN:1410 – 5381

  10. Kapelari  K,, 2008, Pediatric reference intervals for thyroid hormone level from birth to adulthood: a retrospective study, BMC Endocrine Disorders.

  11. Ministry of Health RI. 2012, Direktorat Jenderal Bina Gizi dan Kesehatan Ibu dan AnakPedoman skrining hipotiroid kongenital. Jakarta: Kementerian Kesehatan RI. ISBN 978-602-235-203-7  

  12. Laboratory Corporation of America, 2014, Thyroid cascade testing, Differential Laboratory Diagnosis of Thyroid Dysfunction, a technical review, Lab corp

  13. Martin I, Surks, et al., 2004, Subclinical Thyroid disease, Scientific Review and guidelines for diagnostics and Management, JAMA, Januari  Vol.291 No. 2

  14. Ministry of Health RI (2012).   Pedoman skrining hipotiroid kongenital.  Direktorat Jenderal Bina Gizi dan Kesehatan Ibu dan Anak, Jakarta.

  15. Ministry of Health RI, PMK No 78. Skrining Hipotiroid Kongenital. Jakarta. 2014 dari (

  16. Purnamasari. Penatalaksanaan Perioperatif Hipotiroid. 2007. Hal 2-5 dari ( diakses tanggal 05 Februari 2016

  17. Schteingart, David E. 2006, Gangguan Kelenjar Tiroid Edisi 6. Penerbit Buku Kedokteran EGC. Jakarta.. Hal 1225-1234

  18. Susanto, R, 2009, Kelainan tiroid masa bayi: Skrining hipotiroidisme neonatal, hipotiroidisme kongenital dan  hipotiroidisme didapat, Thyroidology update.

  19. Stockigt, J, 2003, Assesment of Thyroid function: towards an Integrated Laboratory- Clinical Approach, ClinBiochem Rev;24:110-123.

  20. Wibowo, A dan Samsudin, M, 2013 Association Between The Serum Thyroglobulin, Tsh, And Ft4 Among School-Aged Children In Three Districts With Different Iodine-Deficiency Endemicity Level, Penelitian Gizi dan Makanan, Juni Vol. 36 (1): 12-19.

  21. Wirawan A, dkk, 2013, Tumbuh Kembang Anak Hipotiroid Kongenital yang Diterapi dini dengan Levo-tiroksin dan Dosis Awal Tinggi,  Sari Pediatri 15(2):69-74 Indonesia.

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