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Capsule Dosage Forms Containing Natural Antioxidant Microcapsules of Cantigi Extract

Kosasih Kosasih, Fitri Weningtyas

Universitas Pancasila, Indonesia

Microencapsulation technology in product development of the food, beverage, and health sectors may provide innovative products with better stability, functionality, and prolonged releases. This study aims to formulate capsule dosage forms containing natural antioxidant microcapsules of Cantigi extract and analyze slow-release profiles. Three microcapsule formulations (F1, F2, and F3) were made by solvent evaporation method using ethyl cellulose coating and characterized for color, odor, particle size, shape, recovery, moisture content, encapsulation efficiency, drug loading, density, and antioxidant activities. Then, three capsule dosage forms (FI, FII, and FIII) of microcapsules of the most potent antioxidant activity, microcrystalline cellulose, and colloidal silicon dioxide. The results showed that the most potent microcapsules were F1, while the most potent capsule dosage forms were FIII. FIII provides the slowest release compared with FI and FII. By analyzing the kinetics of FIII using zero-order, first-order, Higuchi, and Kosmeyer-Peppas models, the release profile of FIII is the best fit with the first-order model kinetics, consistent with a previous study. Moreover, all capsule dosage forms have a biphasic slow-release profile for 60 minutes. The conclusion is that this study can prepare hard-gelatin capsule dosage forms containing natural antioxidant microcapsules of cantigi extract with first-order and biphasic slow-release profiles.



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