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Asian Institute of Research, Journal Publication, Journal Academics, Education Journal, Asian Institute
Asian Institute of Research, Journal Publication, Journal Academics, Education Journal, Asian Institute

Journal of Health and Medical Sciences

ISSN 2622-7258

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open access

Published: 04 January 2020

Carotid Paragangliomas: Report of 3 Cases and Review of the Literature

Omar El Mahi, Sara Mokhtari, Hussam Al-Zaarir, Mohammed Shamarkha, Taha Abu Altayef, Abdellah Rezziki, Adnane Benzirar

Mohammed VI University Hospital Center (Morocco), Mohammed First University (Morocco)

journal of social and political sciences
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Pages: 12-20

Keywords: Carotid Paraganlioma, Surgical Treatment, Preoperative Embolization, Rare Case Report


Introduction: Carotid Paraganliomas (CP) are relatively rare tumors and usually benign. They appear as a cervical mass of slow and painless evolution, which is often responsible for diagnostic and management delays. Surgery remains the recommended treatment, although there is a risk of neurological and vascular sacrifice for large tumors. The objective of this study is to report our experience and to review the literature on the clinical features, positive diagnosis and management of CP. Methods: It is about a retrospective study of 3 patients with CP who had undergone a surgical resection as a treatment of CP over a period of 5 years from 2013 to 2017. Results: The study concerns 3 female patients without any significant family history. The mean age was 63 years. The tumor has evolved on average 13 years before its diagnosis. The patients were admitted for a firm and incompressible lateral cervical mass on the right side in 2 cases and on the leftside in one case. The surgical treatment consisted on a total resection of the tumor in all cases with a vascular graft interposition in one case. A sacrificed of hypoglossal nerve was required in another case. Pathological examinations of the 3 tumors revealed a benign histology of paragangliomas. The follow-up was simple in 2 cases while one patient presented a transient peripheral facial paralysis. Conclusion: The diagnosis of CP should be evoked towards any firm and painless lateral cervical mass having evolved for several years. Surgical treatment is curative for benign lesions, despite its risks especially in advanced tumors.


  1. Maves, M.D. (1993),” Vascular tumors of the head and neck”.Head and neck-otolaryngology. In: Bailey BJ, Jonhnson JT, Kohut RI, Pillsbury HC,editors. Tardy medical management. Philadelphia: JB Lippincott, p:1397-409.
  2. Gad, A. and Sayed, A. (2014), “Carotid body tumors: a review of 25 years experience in diagnosis and management of 56 tumors”, Ann Vasc Dis. 7(3):292-299.
  3. Irons, G.B., Weiland, L.H. and Brown, W.L. (1977), “Paragangliomas of the neck: clinical and pathological analysis of 116 cases”, Surg Clin North Am, p.57:575-83.
  4. Georgiadis, G.S., Lazarides, M.K., Tsalkidis, A. et al. (2008), “Carotid body tumor in a 13-year-old child: Case report and review of the literature”, J Vasc Surg. 47(4):874-80.
  5. Wienek, J.A. and Smith, A. (2009), “Paraganglioma: carotid body tumor”, Head Neck Pathol. 3(4):303-306.
  6. Kay, J.M. and Laidler, P. (1977), “Hypoxia and the carotid body”, J ClinPatholSuppl (R CollPathol). 11:30-44.
  7. Sobol, S.M. and Dailey, J.C. (1990), “Familial multiple cervical paragangliomas: report of a kindred and review of the literature”, Otolaryngol Head Neck Surg. 102:382-90.
  8. Pacheco-Ojeda, L. (2001), “Malignant carotid body tumors: report of three cases”, Ann OtolRhinolLaryngol. 110:36-40.
  9. Fanning, J.R., Woods, F.M. and Christian, H.J. (1963), “Metastatic carotid body tumor. Report of the case with the review of the literature”, JAMA.185:49.
  10. Myers, E.N. and Johnson, J.T.N. (1993). In: Cummings, C.W., Fredrickson, J.M., Harker, L.A. et al, editors. Otolaryngology-Head and Neck Surgery. St Louis, MO: Mosby Year Book. p. 1590-7.
  11. Evenson, L.J., Mendenhall, W.M., Parsons, J.T. et al. (1998), ”Radiotherapy in the management of chemodectomas of the carotid body and glomusvagale”, Head Neck. 20:609-13.
  12. Grufferman, S., Gillma, M.W., Pasternak, L.R. et al. (1980), “Familial carotid body tumors: case report and epidemiologic review. Cancer” .46(9):2116-2122.
  13. Shamblin, W.R., ReMine, W.H., Sheps, S.G. and Harrison, Jr.EG.(1971), “Carotid body tumor (chemodectoma). Clinicopathologic analysis of ninety cases”, Am J Surg. 122: 732-9.
  14. Jipsa, A. and Janender, P.S. (2018), “Bilateral sporadic carotid body tumors: A rare case report”,Radiology. Case Reports. 13(5): 988-992.
  15. Lees, C.D., Levine, H.L., Beven, E.G. and Tucker, H.M. (1981), “Tumors of the carotid body: experience with 41 operative cases”, Am J Surg. 142:362-5.
  16. Boedeker, C.C. (2011), “Paragangliomas and paraganglioma syndromes. Laryngorhinootologie”,90(Suppl1):S56-82.DOI:10.6061/clinics/2012(Sup01)05
  17. Amato, B., Bianco,T., Compagna, R., Siano, M., Esposito, G., Buffone ,G., Serra, R. and de Franciscis, S. (2014), “Surgical resection of carotid body paragangliomas: 10 years of experience”, Am J Surg. 2014; 207:293-8.
  18. Persky, M.S., Setton, A., Niimi, Y. et al. (2002), “Combined endovascular and surgical treatment of head and neck paragangliomas a team approach”, Head Neck. 24:423-31.
  19. Zeitler, D.M., Glick, J. and Har-El, G. (2010), “Preoperative embolization in carotid body tumor surgery: is it required”, Ann OtolRhinolLaryngol. 119:279-83.
  20. Boedeker, C.C., Ridder, G.J. and Schipper, J. (2005),”Paragangliomas of the head and neck: diagnosis and treatment”, Fam Cancer. 4:55-9.
  21. Anand, V.K., Alemar, G.O. and Sanders, T.S. (1995), “Management of the internal carotid artery during carotid body tumor surgery”, Laryngoscope. 105:231-5.
  22. Law, Y., Chan, Y.C. and Cheng, S.W. (2017), “Surgical management of carotid body tumor - is Shamblin classification sufficient to predict surgical outcome? “, Vascular. 25(2):184-189.
  23. Sajid, M.S., Hamilton, G., Baker, D.M. et al. (2007), ” A multicenter review of carotid body tumour management”,Eur J VascEndovasc Surg. 34(2):127-130.
  24. JianbinZhanga, XueqiangFana, YananZhena, Jie Chena, Xia Zhenga, Bo Maa, RongweiXub, JieKonga, Zhidong Yea, PengLiua. (2018), “Impact of preoperative transarterial embolization of carotid body tumor: A single center retrospective cohort experience International”, Journal of Surgery. 54:48-52.
  25. Carroll, W., Stenson, K. and Stringer, S. (2004) ,” Malignant carotid body tumor”, Head Neck. 26(3):301-306.
  26. Zabel, A., Milker-Zabel, S., Huber, P. and al. (2004), “Fractionated stereotactic conformal radiotherapy in the management of large chemodectomas of the skull base”, Int J RadiatOncolBiol Phys. 58:1445-50.
  27. Schick, P.M., Hieshima, G.B., White, R.A. et al. (1980), “Arterial catheter embolization followed by surgery for large chemodectoma. Surgery” .87(4):459-464.
  28. Jackson, R.S., Myhill, J.A., Padhya, T.A. et al. (2015), “The effects of preoperative embolization on carotid body paraganglioma surgery: a systematic review and metaanalysis”, Otolaryngol Head Neck Surg. 153(6):943-950.
  29. Vogel, T.R., Mousa, A.Y., Dombrovskiy, V.Y., Haser, P.B. and Graham, A.M. (2009), “Carotid body tumor surgery: management and outcomes in the nation”, Vasc Endovascular Surg. 43:457-61.
  30. Litle, V.R., Reilly, L.M. and Ramos, T.K. (1996), “Preoperative embolization of carotid body tumors: when is it appropriate”, Ann Vasc Surg. 10:464-8.
  31. Liapis, C.D., Evangelidakis, E.L., Papavassiliou, V.G., Kakiskas, J.D., Gougoulakis, A.G., Polyzos, A.K. et al. (2000), “Role of malignancy and preoperative embolization in the management of carotid body tumors”, World J Surg. 24:1526-30.
  32. Harman, M., Etlik, O. and Unal, O. (2004), “Direct percutaneous embolization of a carotid body tumor with n-butyl cyanoacrylate: an alternative method to endovascular embolization”, ActaRadiol. 45(6):646-648.
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