Probiotics for Cardiovascular Diseases, Hypertension, Hypercholesterolemia, and Cancer Condition: A Summary of the Evidence
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Asian Institute of Research, Journal Publication, Journal Academics, Education Journal, Asian Institute
Asian Institute of Research, Journal Publication, Journal Academics, Education Journal, Asian Institute

Journal of Health and Medical Sciences

ISSN 2622-7258

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Published: 15 April 2019

Probiotics for Cardiovascular Diseases, Hypertension, Hypercholesterolemia, and Cancer Condition: A Summary of the Evidence

Mohammad Asadul Habib, Md. Abdullah Al Mamun, Md. Ruhul Kabir, Mohammad Hasan Chowdhury, Farzana Afroz Tumpa, Jannatul Nayeem

Noakhali Science and Technology University, Bangladesh

journal of social and political sciences
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doi

10.31014/aior.1994.02.02.30

Pages: 131-141

Keywords: Cholesterol, Functional Foods, Bifidobacteria, Cancer, Hypertention

Abstract

For a few decades, bacteria called probiotics have been added to some foods because of their salutary effects for human health. Although only various clinical studies have been conducted, that probiotic could be feasible in obstructing and treating some leading diseases such as cardiovascular disease, hypertension, hypercholesterolemia, cancer & other potential diseases. Probiotics have been suggested to reduce cholesterol via various mechanisms without any deleterious effect on human health. Among their various effects, anti-cancer properties have been highlighted in recent years. Such effect includes suppression of the growth of microbiota implicated in the production of mutagens and carcinogens, alteration in carcinogen metabolism and protection of DNA from oxidative damage as well as regulation of the immune system. Outcomes from animals and human studies suggest a tolerable cholesterol-lowering action of dairy products fermented with adequate strain(s) of LAB (lactic acid bacteria) and bifidobacteria. Mechanistically, probiotic bacteria ferment food-derived indigestible carbohydrates to produce short-chain fatty acids in the gastrointestinal tract, which can then cause a reduction in the systemic levels of blood lipids by suppressing hepatic cholesterol synthesis and/or redistributing cholesterol from plasma to the liver. Besides, some bacteria may intervene with cholesterol absorption from the gut by deconjugating bile salts and therefore affecting the metabolism of cholesterol, or by directly embodying cholesterol which is then helpful for reducing coronary heart disease, including hypertension and hypercholesterolemia. In this review, we will focus mainly on reviewing existing studies concerning the effects of probiotic food in ameliorating health and treating diseases particularly cardiovascular diseases, hypertension, hypercholesterolemia & cancer.

References

  1. Aihara, K., Kajimoto, O., Hirata, H., Takahashi, R. and Nakamura, Y., 2005. Effect of powdered fermented milk with Lactobacillus helveticus on subjects with high-normal blood pressure or mild hypertension. Journal of the American College of Nutrition, 24(4), pp.257-265.

  2. Altermann, E., Russell, W.M., Azcarate-Peril, M.A., Barrangou, R., Buck, B.L., McAuliffe, O., Souther, N., Dobson, A., Duong, T., Callanan, M. and Lick, S., 2005. Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM. Proceedings of the National Academy of Sciences, 102(11), pp.3906-3912.

  3. Appel, L.J., Moore, T.J., Obarzanek, E., Vollmer, W.M., Svetkey, L.P., Sacks, F.M., Bray, G.A., Vogt, T.M., Cutler, J.A., Windhauser, M.M. and Lin, P.H., 1997. A clinical trial of the effects of dietary patterns on blood pressure. New England Journal of Medicine, 336(16), pp.1117-1124.

  4. Ataie-Jafari, A., Larijani, B., Majd, H.A. and Tahbaz, F., 2009. Cholesterol-lowering effect of probiotic yogurt in comparison with ordinary yogurt in mildly to moderately hypercholesterolemic subjects. Annals of Nutrition and Metabolism, 54(1), pp.22-27.

  5. Begley, M., Hill, C. and Gahan, C.G., 2006. Bile salt hydrolase activity in probiotics. Appl. Environ. Microbiol., 72(3), pp.1729-1738.

  6. Bhathena, J., Martoni, C., Kulamarva, A., Urbanska, A.M., Malhotra, M. and Prakash, S., 2009. Orally delivered microencapsulated live probiotic formulation lowers serum lipids in hypercholesterolemic hamsters. Journal of Medicinal Food, 12(2), pp.310-319.

  7. Charteris, W.P., Kelly, P.M., Morelli, L. and Collins, J.K., 1997. Selective detection, enumeration and identification of potentially probiotic Lactobacillus and Bifidobacterium species in mixed bacterial populations. International journal of food microbiology, 35(1), pp.1-27.

  8. Cho, S.S., Finocchiaro, E.T. (Eds.), 2010. Handbook of Prebiotics and Probiotics Ingredients Health Benefits and Food Application. CRC Press Taylor & Francis Group, New York, pp. 435.

  9. Danielson, A.D., Peo Jr, E.R., Shahani, K.M., Lewis, A.J., Whalen, P.J. and Amer, M.A., 1989. Anticholesteremic property of Lactobacillus acidophilus yogurt fed to mature boars. Journal of Animal Science, 67(4), pp.966-974.

  10. El-Nezami, H. S., Polychronaki, N. N., Ma, J., Zhu, H., Ling, W., Salminen, E. K., ... & Mykkänen, H. M. (2006). Probiotic supplementation reduces a biomarker for increased risk of liver cancer in young men from Southern China. The American journal of clinical nutrition, 83(5), 1199-1203.

  11. Eckburg, P.B., Bik, E.M., Bernstein, C.N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S.R., Nelson, K.E., Relman, D.A., 2005. Diversity of the human intestinal microbial flora. Science 308, 1635–1638.

  12. Gilliland, S.E., Nelson, C.R. and Maxwell, C., 1985. Assimilation of cholesterol by Lactobacillus acidophilus. Appl. Environ. Microbiol., 49(2), pp.377-381.

  13. Gismondo, M.R., Drago, L. and Lombardi, A., 1999. Review of probiotics available to modify gastrointestinal flora. International journal of antimicrobial agents, 12(4), pp.287-292.

  14. Hylemon, P.B., 1985. Metabolism of bile acids in intestinal microflora. In New comprehensive biochemistry (Vol. 12, pp. 331-343).

  15. Jones, R.M., Luo, L., Ardita, C.S., Richardson, A.N., Kwon, Y.M., Mercante, J.W., Alam, A., Gates, C.L., Wu, H., Swanson, P.A. and Lambeth, J.D., 2013. Symbiotic lactobacilli stimulate gut epithelial proliferation via Nox‐mediated generation of reactive oxygen species. The EMBO journal, 32(23), pp.3017-3028.

  16. Jones, B.V., Begley, M., Hill, C., Gahan, C.G. and Marchesi, J.R., 2008. Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome. Proceedings of the national academy of sciences, 105(36), pp.13580-13585.

  17. Kimura, K., McCartney, A. L., McConnell, M. A., & Tannock, G. W. (1997). Analysis of fecal populations of bifidobacteria and lactobacilli and investigation of the immunological responses of their human hosts to the predominant strains. Appl. Environ. Microbiol., 63(9), 3394-3398.

  18. Kamal, R., Dahiya, P., Kumar, M. and Tomar, V., 2013. Probiotics in oral health–A new tool in pharmaceutical science. Indian J Pharm Biol Res, 1(4), pp.168-73.

  19. Kim, E.K., An, S.Y., Lee, M.S., Kim, T.H., Lee, H.K., Hwang, W.S., Choe, S.J., Kim, T.Y., Han, S.J., Kim, H.J. and Kim, D.J., 2011. Fermented kimchi reduces body weight and improves metabolic parameters in overweight and obese patients. Nutrition Research, 31(6), pp.436-443.

  20. Klaver, F.A. and Van Der Meer, R., 1993. The assumed assimilation of cholesterol by Lactobacilli and Bifidobacterium bifidum is due to their bile salt-deconjugating activity. Appl. Environ. Microbiol., 59(4), pp.1120-1124.

  21. Li, G., 2012. Intestinal probiotics: interactions with bile salts and reduction of cholesterol. Procedia Environmental Sciences, 12, pp.1180-1186.

  22. Lahtinen, S.J., Gueimonde, M., Ouwehand, A.C., Reinikainen, J.P. and Salminen, S.J., 2005. Probiotic bacteria may become dormant during storage. Appl. Environ. Microbiol., 71(3), pp.1662-1663.

  23. Liu, Z. H., Huang, M. J., Zhang, X. W., Wang, L., Huang, N. Q., Peng, H., ... & Liu, W. J. (2012). The effects of perioperative probiotic treatment on serum zonulin concentration and subsequent postoperative infectious complications after colorectal cancer surgery: a double-center and double-blind randomized clinical trial. The American journal of clinical nutrition, 97(1), 117-126.

  24. Meyer, D. and Stasse-Wolthuis, M., 2009. The bifidogenic effect of inulin and oligofructose and its consequences for gut health. European journal of clinical nutrition, 63(11), p.1277.

  25. Marteau, P.R., Vrese, M.D., Cellier, C.J. and Schrezenmeir, J., 2001. Protection from gastrointestinal diseases with the use of probiotics. The American journal of clinical nutrition, 73(2), pp.430s-436s.

  26. Martin, F.P.J., Dumas, M.E., Wang, Y., Legido‐Quigley, C., Yap, I.K., Tang, H., Zirah, S., Murphy, G.M., Cloarec, O., Lindon, J.C. and Sprenger, N., 2007. A top‐down systems biology view of microbiome‐mammalian metabolic interactions in a mouse model. Molecular systems biology, 3(1), p.112.

  27. Menrad, K., 2003. Market and marketing of functional food in Europe. Journal of food engineering, 56(2-3), pp.181-188.

  28. Mann, G.V. and Spoerry, A., 1974. Studies of a surfactant and cholesteremia in the Maasai. The American journal of clinical nutrition, 27(5), pp.464-469.

  29. Mattila-Sandholm, T., Myllärinen, P., Crittenden, R., Mogensen, G., Fondén, R. and Saarela, M., 2002. Technological challenges for future probiotic foods. International Dairy Journal, 12(2-3), pp.173-182.

  30. Ma, E. L., Choi, Y. J., Choi, J., Pothoulakis, C., Rhee, S. H., & Im, E. (2010). The anticancer effect of probiotic Bacillus polyfermenticus on human colon cancer cells is mediated through ErbB2 and ErbB3 inhibition. International journal of cancer, 127(4), 780-790.

  31. Narang, S., Gupta, R. and Narang, A., 2011. Probiotics in oral healthcare–A review. Int J Sci Eng Res, 2, pp.1-5.

  32. Nakamura, Y., Yamamoto, N., Sakai, K. and Takano, T., 1995. Antihypertensive effect of sour milk and peptides isolated from it that are inhibitors to angiotensin I-converting enzyme. Journal of dairy science, 78(6), pp.1253-1257.

  33. Özer, D., Akin, S. and Özer, B., 2005. Effect of inulin and lactulose on survival of Lactobacillus acidophilusla-5 and Bifidobacterium bifidum bb-02 in Acidophilus-bifidus yoghurt. Food Science and Technology International, 11(1), pp.19-24.

  34. Ohashi, Y., Nakai, S., Tsukamoto, T., Masumori, N., Akaza, H., Miyanaga, N., ... & Naito, S. (2002). Habitual intake of lactic acid bacteria and risk reduction of bladder cancer. Urologia Internationalis, 68(4), 273-280.

  35. O'mahony, L., Feeney, M., O'halloran, S., Murphy, L., Kiely, B., Fitzgibbon, J., Lee, G., O'sullivan, G., Shanahan, F. and Collins, J.K., 2001. Probiotic impact on microbial flora, inflammation and tumour development in IL‐10 knockout mice. Alimentary pharmacology & therapeutics, 15(8), pp.1219-1225.

  36. Parker, R.B., 1974. Probiotics, the other half of the antibiotic story. Anim Nutr Health, 29, pp.4-8.

  37. Rao, B.N., 2003. Bioactive phytochemicals in Indian foods and their potential in health promotion and disease prevention. Asia Pacific Journal of clinical nutrition, 12(1).

  38. Rašić, J.L., Vujičić, I.F., Škrinjar, M. and Vulić, M., 1992. Assimilation of cholesterol by some cultures of lactic acid bacteria and bifidobacteria. Biotechnology letters, 14(1), pp.39-44.

  39. Remacle, C. and Reusens, B. eds., 2004. Functional foods, ageing and degenerative disease.

  40. Saarela, M., Lahteenmaki, L., Crittenden, R., Salminen, S., Mattila-Sandholm, T., 2002. Gut bacteria and health foods—the European perspective. Int. J. Food Microbiol. 78, 99–117.

  41. Salminen, S., von Wright, A., Morelli, L., Marteau, P., Brassart, D., de Vos, W.M., Fondén, R., Saxelin, M., Collins, K., Mogensen, G. and Birkeland, S.E., 1998. Demonstration of safety of probiotics—a review. International journal of food microbiology, 44(1-2), pp.93-106.

  42. Srionnual, S., Yanagida, F., Lin, L.H., Hsiao, K.N. and Chen, Y.S., 2007. Weissellicin 110, a newly discovered bacteriocin from Weissella cibaria 110, isolated from plaa-som, a fermented fish product from Thailand. Appl. Environ. Microbiol., 73(7), pp.2247-2250.

  43. Salminen, S., Isolauri, E., 2006. Intestinal colonization, microbiota, and probiotics. J. Pediatr. 149, 115–120.

  44. Seppo, L., Jauhiainen, T., Poussa, T. and Korpela, R., 2003. A fermented milk high in bioactive peptides has a blood pressure–lowering effect in hypertensive subjects. The American journal of clinical nutrition, 77(2), pp.326-330.

  45. Stanton, C., Gardiner, G., Meehan, H., Collins, K., Fitzgerald, G., Lynch, P.B. and Ross, R.P., 2001. Market potential for probiotics. The American journal of clinical nutrition, 73(2), pp.476s-483s.

  46. Shah, N.P., 2007. Functional cultures and health benefits. International dairy journal, 17(11), pp.1262-1277.

  47. Toi, M., Hirota, S., Tomotaki, A., Sato, N., Hozumi, Y., Anan, K., Nagashima, T., Tokuda, Y., Masuda, N., Ohsumi, S. and Ohno, S., 2013. Probiotic beverage with soy isoflavone consumption for breast cancer prevention: A case-control study. Current Nutrition & Food Science, 9(3), pp.194-200.

  48. Tuomola, E., Crittenden, R., Playne, M., Isolauri, E. and Salminen, S., 2001. Quality assurance criteria for probiotic bacteria. The American Journal of Clinical Nutrition, 73(2), pp.393s-398s.

  49. Usman, Hosono, A., 1999. Bile tolerance, taurocholate deconjugation, and binding of cholesterol by lactobacillus gasseri strains. J. Dairy Sci. 82, 243–248.

  50. Wang, Y., Xu, N., Xi, A., Ahmed, Z., Zhang, B. and Bai, X., 2009. Effects of Lactobacillus plantarum MA2 isolated from Tibet kefir on lipid metabolism and intestinal microflora of rats fed on high-cholesterol diet. Applied Microbiology and Biotechnology, 84(2), pp.341-347.

  51. Xu, J. and Gordon, J.I., 2003. Honor thy symbionts. Proceedings of the National Academy of Sciences, 100(18), pp.10452-10459.

  52. Yamamoto, N., Akino, A. and Takano, T., 1994. Antihypertensive effect of the peptides derived from casein by an extracellular proteinase from Lactobacillus helveticus CP790. Journal of dairy science, 77(4), pp.917-922.

  53. Ziemer, C.J. and Gibson, G.R., 1998. An overview of probiotics, prebiotics and synbiotics in the functional food concept: perspectives and future strategies. International Dairy Journal, 8(5-6), pp.473-479.

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