Synthesis and Characterization of Benzofuranone and its Derivatives
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Asian Institute of Research, Journal Publication, Journal Academics, Education Journal, Asian Institute
Asian Institute of Research, Journal Publication, Journal Academics, Education Journal, Asian Institute

Engineering and Technology Quarterly Reviews

ISSN 2622-9374

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Published: 09 December 2022

Synthesis and Characterization of Benzofuranone and its Derivatives

Mohammad Ali Nasiri, Abdulraouf Rashid, Bonyad Ali Moin, Azizullah Yosufi, Ismael Ahmadi, Mohammad Haidar Mosavi

Bamyan University (Afghanistan), Kabul Education University (Afghanistan)

journal of social and political sciences
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doi

10.5281/zenodo.7415309

Pages: 58-64

Keywords: Salicylaldehyde, TLC, DCM, Mobile Phase, Anhydrous Sodium Sulfate and Reflux

Abstract

In this experiment a mixture of salicylaldehyde (2 mmol), 4-chlorophenacyl bromide (2 mmol) and potassium tertiary butoxid (T-BuOK) (2mmol) in 10ml of Dichlorometane (DCM), containing molecular sieves was reflexed at 30C^°for 3 hours. Progress of the reaction was monitored by Thin layer chromatography (TLC) using hexane: ethyl acetate (8:2) mixture as mobile phase. After the completion of the reaction, the reaction mixture was washed with 10 % HCl solution followed by water. The organics were dried over anhydrous sodium sulfate. The yellow solid was obtained disolventizing in a rotary evaporator at room temperature affords benzofuran-2-yl (4-chlorophenyl) methanone. Benzofuranone (0.60 ml, 5 mmol) with substituted anilines (5 mmol) in round bottom flasks was refluxed in 15 ml methanol at 40C^° for 3 hours in the presence of 1.5 ml glacial acetic acid. In each case, the precipitated base was filtered off, recrystallized from absolute ethanol and dried in vacuum desiccators. The (Z)-N-(benzofuran-2-yl (4-chlorophenyl) methylene) aniline was obtained.

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