top of page
Asian Institute of Research, Journal Publication, Journal Academics, Education Journal, Asian Institute
Asian Institute of Research, Journal Publication, Journal Academics, Education Journal, Asian Institute

Journal of Health and Medical Sciences

ISSN 2622-7258

Screen Shot 2018-08-12 at 1.24.09 AM.png
Screen Shot 2018-08-12 at 1.24.02 AM.png
Screen Shot 2018-08-12 at 1.23.57 AM.png
Screen Shot 2018-08-12 at 1.23.52 AM.png
open access

Published: 11 October 2021

Chemical Compound of Terminalia Catappa L. as Hemostatic Agents in Post Tooth Extraction

Ni Made Sirat, Asep Arifin Senjaya

Poltekkes Kemenkes Bali, Indonesia

journal of social and political sciences
pdf download

Download Full-Text Pdf



Pages: 16-26

Keywords: Terminalia Catappa L., Hemostatic, Tooth Extraction


Terminalia catappa L. is one of the herbal plants that contain flavonoids that play a role in wound healing including to bleeding after tooth extraction. The aim of our study was to identify the chemical compounds contained in Terminalia catappa L. leaves. This type of research was experimental. The sample in this study was the leaves of Terminalia catappa number 3-6 from the base, at a tree height of 6 meters picked as much as 6 kilograms. Data analysis qualitatively and quantitatively. The highest content in ethanol extract of Terminalia catappa L of saponins and alkaloids were fractioned with distilled water and the lowest content were fractioned with hexane. Meanwhile distilled water is also used to fractioned the highest content of tannins and phenol. While ethyl acetate was used to fractioned the lowest content of tannins and the highest content of flavonoid. The lowest flavonoid in distilled water extract was fractioned using hexane. For the lowest content of phenol was fractioned using hexane. The results show the highest content of saponins is 3,787.80 mg/100g, the lowest is 166.67 mg/100g. The highest content of Alkaloids is 1,798.57 mg/100g, and the lowest is 576.80 mg/100g. The highest content of tannins is 53,140.72 mg/100g, the lowest is 8,391,803 mg/100g. The highest content of flavonoids is 2,5964.14 mg/100g, the lowest flavonoid is 462.84 mg/100g. The highest content of phenol 29,968.05 mg/100g, the lowest is 225.46 mg/100g. The highest antioxidant activity with AAI (Antioxidant Activity Index) obtains value of 0.36. This shows the moderate antioxidant ability. Terminalia catappa L. contain saponins, alkaloids, tannins, flavonoids, and triterpenoids. The active compound of Terminalia catappa L will generally be produced optimally if a polar solvent is used.


  1. Abarca-vargas, R., Malacara, C. F. P., & Petricevich, V. L. (2016). Characterization of Chemical Compounds with Antioxidant and Cytotoxic Activities in Bougainvillea x buttiana Holttum and Standl , ( var . Rose ) Extracts. Antioxidants, 5(45), 1–11.

  2. Babayi, H., Kolo, I., Okogun, J. I., & Ijah, U. J. J. (2004). The antimicrobial activities of methanolic extracts of Eucalyptus camaldulensis and Terminalia catappa against some pathogenic microorganisms. Biokemistri, 16(December), 106–111.

  3. Bahrin, N., Muhammad, N., Abdullah, N., Talip, B. H. A., Jusoh, S., & Theng, S. W. (2018). Effect of Processing Temperature on Antioxidant Activity of Ficus carica Leaves Extract. Journal of Science and Technology, 10(2), 99–103.

  4. Ekor, M. (2014). The growing use of herbal medicines : issues relating to adverse reactions and challenges in monitoring safety. Frontiers in Pharmacology, 4(January), 1–10.

  5. Etienne, D. T., Ah, K. K. C., Yves, N., Constant, K., Adama, C., Daouda, S., … Marius, B. G. H. (2017). Antioxidants Contents of Terminalia catappa ( Combretaceae ) Almonds Grown in Côte d ’ Ivoire. Archives of Current Research International, 10(3), 1–12.

  6. Filho, A. K. D. B., Fernandes, E. S., & Monteiro, C. D. A. (2017). Phytochemical Characterization of Terminalia catappa Linn . Extracts and Their antifungal Activities against Candida spp . Frontiers in Microbiology, 8(April), 1–13.

  7. Gao, J., Tang, X., Dou, H., Fan, Y., Zhao, X., & Xu, Q. (2004). Hepatoprotective activity of Terminalia catappa L . leaves and its two triterpenoids. Journal of Pharmacy and Pharmacoloty, 56, 1449–1455.

  8. Gonzalez, A. C. de O., Andrade, Z. de A., Costa, T. F., & Medrado, A. R. A. P. (2016). Wound healing - A literature review. An Bras Dermatol, 91(5), 614–620.

  9. Herli, M. A., & Wardaniati, I. (2019). Skrining Fitokimia Ekstrak Etanol dan Fraksi Daun Ketapang yang Tumbuh di Sekitar Univ. Abdurrab, Pekanbaru. Journal Of Pharmacy & Science, 2(2), 38–42.

  10. Irawati, F., & Nita, P. (2012). Kajian Ekstraksi dari Daun Ketapang. Universitas Pembangunan Nasional Veteran Jawa Timur.

  11. Janporn, S., Ho, C., Chavasit, V., Pan, M., Chittrakorn, S., Ruttarattanamongkol, K., & Weerawatanakorn, M. (2014). Physicochemical properties of Terminalia catappa seed oil as a novel dietary lipid source. Journal of Food and Drug Analysis, 23(2), 201–209.

  12. Katiki, L. M., Gomes, A. C. P., Barbieri, A. M. E., Pacheco, P. A., Rodrigues, L., Veríssimo, C. J., … Ferreira, J. F. S. (2017). Veterinary Parasitology Terminalia catappa : Chemical composition , in vitro and in vivo effects on Haemonchus contortus. Veterinary Parasitology, 246(September), 118–123.

  13. Khan, A. A., Kumar, V., Singh, B. K., & Singh, R. (2014). Evaluation of Wound Healing Property of Terminalia catappa on Excision Wound Models in Wistar Rats. Drug Res, 64(October), 225–228.

  14. Kopeliovich, D. (2017). Classification of solvents. Retrieved September 20, 2021, from

  15. Lin, Y.-L., Kuo, Y.-H., Shiao, M.-S., Chen, C.-C., & Ou, J.-C. (2000). Flavonoid Glycosides from Terminalia catappa L. Journal of the Chinese Chemical Society, 585(47), 253–256.

  16. Mininel, F. J., Sérgio, C., Junior, L., Espanha, L. G., Resende, F. A., Varanda, E. A., … Campaner, L. (2014). Characterization and Quantification of Compounds in the Hydroalcoholic Extract of the Leaves from Terminalia catappa Linn . ( Combretaceae ) and Their Mutagenic Activity. Evidence-Based Complementary and Alternative Medicine, 2014, 1–11.

  17. Muhammad, A., & Mudi, S. Y. (2011). Phytochemical Screening and Antimicrobial Activities of Terminalia catappa , Leaf Extracts. Biokemistri, 23(1), 35–39.

  18. Muthulakshmi, G., & Neelanarayanan, P. (2021). Evaluation of Antimicrobial Activities of Terminalia catappa Leaves ’ Extracts against Bacterial and Fungal Pathogens. Indian Journal of Natural Sciences, 11(64), 976–997.

  19. Nabavizadeh, M. R., Zargaran, A., Moazami, F., Askari, F., Sahebi, S., Farhadpoor, A., & Faridi, P. (2016). Comparison of the Hemostatic Activity of Quercus persica Jaub . & Spach . ( Oak ) With Ferric Sulfate in Bony Crypts. Journal of Evidence-Based Complementary & Alternative Medicine, 21(1), 34–38.

  20. Nagraj, S. K., Prashanti, E., & Aggarwal, H. (2018). Interventions for treating post-extraction bleeding. Cochrane Database of Systematic Reviews, (3), 1–22.

  21. Nugroho, R. A., Aryani, R., Manurung, H., Rudianto, & Prameswari, D. (2019). Wound healing potency of Terminalia catappa in mice ( Mus musculus ). Eurasia J Biosci, 13(December), 2337–2342.

  22. Ola, P. D., Sandri, M. I., Ola, A. R. B., & Kadang, L. (2020). Determination of Total Tanin Contents of Terminalia Catappa L. Leaf Extract and Test of Its Ability as A Complexion Agent of Fe (III). Chem. Notes, 1(2), 94–107.

  23. Punniyakotti, P., Rengarajan, R. L., Velayuthaprabhu, S., Vijayakumar, K., Manikandan, R., Anand, A. V., … Vijaya, A. (2019). Protective Effect of Terminalia catappa Leaves and Terminalia chebula Fruits on the Enzymatic and Non-enzymatic Anti-oxidant Levels in the Doxorubicin Induced Toxicity Rats. Pharmacogn J, 11(2), 346–349.

  24. Purwaningsih, P. P., Darmayasa, I. B. G., & Astiti, N. P. A. (2020). Early Elucidation Of The Resistor Efficacy Of The Ethanol Ekstract Of The Leaf Of “Ketapang” (Terminalia Catappa L.) Against The Growth Of Staphylococcus Aureus ATCC25923 Which Is The Cause Of Gingivitist. Journal of Biological Sciences, 7(1), 57–64.

  25. Rahardjo, A. P., Fauzantoro, A., & Gozan, M. (2019). Fractionation and Characterization of Semi Polar and Polar Compounds from Leaf Extract Nicotiana tabaccum L . Reflux Ethanol Extraction Results. In AIP Conference Proceedings (Vol. 030022, pp. 1–9).

  26. Raynor, D. K., Dickinson, R., Knapp, P., Long, A. F., & Nicolson, D. J. (2011). Buyer beware ? Does the information provided with herbal products available over the counter enable safe use ? Buyer beware ? Does the information provided with herbal products available over the counter enable safe use ? BMC Medicine, 94(August), 1–8.

  27. Santoso, B., Imaduddin, F., Sukanto, H., Triyono, J., Lambang, R. L., Widodo, P. J., & Siswantoro, D. H. (2021). Mekanika : Majalah Ilmiah Mekanika Procurement and Operation Technical For Meniran ( Phyllanthus Niruri ) Extraction Equipment. Mekanika: Majalah Ilmiah Mekanika, 20(March), 34–43.

  28. Shah, P., & Modi, H. A. (2016). Comparative Study of DPPH , ABTS and FRAP Assays for Determination of Antioxidant Activity. International Journal for Research in Applied Science and Engineering Technology (IJRASET), 3(6), 636–641.

  29. Singh, R., Verma, P. K., & Singh, G. (2012). Total phenolic , flavonoids and tannin contents in different extracts of Artemisia absinthium. Journal of Intercultural Ethnopharmacology, 1(2), 101–104.

  30. Sutopo, T., Bestari, R. S., & Sintowati, R. (2016). The Effect of The 70% Ethanol Extract of Betel Leaf (Piper Bettle L.) on Bleeding Time in Mice Swiss Webster Strain. Biomedika, 8(2), 54–61.

  31. Tampemawa, P. V, Pelealu, J. J., & Kandou, F. E. F. (2016). Uji Efektivitas Ekstrak Daun Ketapang (Terminalia catappa L.) Terhadap Bakteri Bacillus amyloliquefaciens. Pharmacon, 5(1), 308–320.

  32. Vasi, S. M., Stefanovi, O. D., Li, B. Z., & Radojevi, I. D. (2012). Biological Activities of Extracts from Cultivatied Granadilla Passiflora Alata. EXCLI, 11, 208–218.

bottom of page