The Hemoglobin Levels and Characteristics in Malaria Endemic Region in Eastern Indonesia
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Asian Institute of Research, Journal Publication, Journal Academics, Education Journal, Asian Institute
Asian Institute of Research, Journal Publication, Journal Academics, Education Journal, Asian Institute

Journal of Health and Medical Sciences

ISSN 2622-7258

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doi
open access

Published: 27 January 2020

The Hemoglobin Levels and Characteristics in Malaria Endemic Region in Eastern Indonesia

Naufal F. Nugraha, Nisa Fauziah, Lia Faridah, Jontari Hutagalung

Universitas Padjadjaran (Indonesia), National Institute of Health Research and Development, Ministry of Health (Indonesia)

journal of social and political sciences
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doi

10.31014/aior.1994.03.01.95

Pages: 41-48

Keywords: East Indonesia, Hemoglobin, Malaria Endemic

Abstract

Introductions: Anemia is the most common symptoms to appear in malaria infection. Hb levels in malaria infection are one of the benchmarks to determine whether or not a patient is anemic as a predictor of the severity of infection. Malarial anemia is capable of causing severe morbidity and mortality especially in children and pregnant women infected. The most prevalent etiology of malaria in Indonesia is P. falciparum (52%) and P. vivax (38%). There is no specific study about Hb level in the community in an endemic area. Accurate clinical diagnoses are necessary to determine the local specific malaria symptoms. Objectives: This study was conducted to assess the different of Hb levels between malaria P. falciparum and P. vivax in eastern Indonesia. Methods: This is a cross-sectional study using secondary data in 2013-2014 from 5 sub-districts in South Central Timor Regency. Data was collected and analyzed using bivariate and multivariate analysis with 95% confidence interval (CI) and α= 0.05. Results: Data consisting of 152 respondents were collected. 62,5% (95/152) were infected P. vivax and 37.5% (57/152) infected with the P. falciparum. Mean of Hb levels from P. falciparum 11.130 g/dL and P. vivax 11.296 g/dL. T-test resulted the value of p-value 0.672 (p-value >0.05) with MD 0.166, 95% CI -0.938-1.606, while multiple linear regression showed regression coefficient -0.059 and p-value 0.876 (p-value >0.05) for Hb levels on P. falciparum and P. vivax-infected patients. Conclusion: The average level of Hb in P. falciparum-infected patients is relatively lower than P. vivax-infected patients.

References

  1. Ademolue, T. W., Aniweh, Y., Kusi, K. A., & Awandare, G. A. (2017). Patterns of inflammatory responses and parasite tolerance vary with malaria transmission intensity. Malaria Journal, 16(1), 145.
  2. Afdhal, M. J., Nurhayati, N., & Julizar, J. (2014). Membandingkan Status Hematologis Pasien Malaria Falciparum dengan Vivax di RSUP M. Djamil Januari 2011–Maret 2013. Jurnal Kesehatan Andalas, 3(3).
  3. Ahmad, N., Drew, W. L., Lagunoff, M., Pottinger, P., Reller, L. B., & Sterling, C. R. (2014). Sherris Medical Microbiology. (K. J. Ryan & C. G. Ray, Eds.) (6th ed.). McGraw-Hill Education.
  4. Buku Saku Tatalaksana Malaria. (2017). Jakarta: Subdit Malaria Direktorat P2PTVZ Kementerian Kesehatan Republik Indonesia.
  5. Cappellini, M. D., & Motta, I. (2015). Anemia in clinical practice—definition and classification: does hemoglobin change with aging? In Seminars in hematology (Vol. 52, pp. 261–269). Elsevier.
  6. Chakraborty, A. (2016). Malaria: An Ancient Disease yet a Global Concern. LS: International Journal of Life Sciences, 5(1), 14–19.
  7. Chhabra, G. (2018). Automated hematology analyzers: Recent trends and applications. Journal of Laboratory Physicians, 10(1), 15.
  8. Cox, F. E. G. (2010). History of the discovery of the malaria parasites and their vectors. Parasites & Vectors, 3(1), 5.
  9. Direktorat Jenderal Pencegahan dan Pengendalian Penyakit. (2018). Situasi Terkini Perkembangan Program Pengendalian Malaria di Indonesia Tahun 2018. Jakarta: Kementerian Kesehatan Republik Indonesia.
  10. Elyazar, I. R. F., Hay, S. I., & Baird, J. K. (2011). Malaria distribution, prevalence, drug resistance and control in Indonesia. In Advances in parasitology (Vol. 74, pp. 41–175). Elsevier.
  11. HemoCue, A. B. (2013). HemoCue Hb 201+ Operating Manual. HemoCue AB, Ängelholm, Sweden. ND.
  12. Hutagalung, J., Kusnanto, H., Sadewa, A. H., & Satyagraha, A. W. (2018). The first evaluation of glucose-6-phosphate dehydrogenase deficiency (G6PD) gene mutation in malaria-endemic region at South Central Timor (SCT) district, Eastern Indonesia 2015-2016. In IOP Conference Series: Earth and Environmental Science (Vol. 125, p. 12016). IOP Publishing.
  13. Ihekwereme, C. P., Esimone, C. O., & Nwanegbo, E. C. (2014). Hemozoin inhibition and control of clinical malaria. Advances in Pharmacological Sciences, 2014.
  14. Irawan, H., Merry, M. S., & Wuryaningsih, N. S. (2017). Profil Hematologik Berdasarkan Jenis Plasmodium pada Pasien Malaria Rawat Inap di RSK Lindimara, Sumba Timur. Berkala Ilmiah Kedokteran Duta Wacana, 2(2), 393–402.
  15. Khan, W., & Zakai, H. (2014). Clinico-pathological studies of Plasmodium falciparum and Plasmodium vivax—malaria in India and Saudi Arabia. Acta Parasitologica, 59(2), 206–212.
  16. Kotepui, M., Piwkham, D., PhunPhuech, B., Phiwklam, N., Chupeerach, C., & Duangmano, S. (2015). Effects of malaria parasite density on blood cell parameters. PLoS One, 10(3).
  17. Mitra, S., Abhilash, K. P. P., Arora, S., & Miraclin, A. (2015). A prospective study from south India to compare the severity of malaria caused by Plasmodium vivax, P. falciparum and dual infection. Journal of Vector Borne Diseases, 52(4), 281.
  18. Murphy, W. G. (2014). The sex difference in haemoglobin levels in adults—mechanisms, causes, and consequences. Blood Reviews, 28(2), 41–47.
  19. Natalia, D. (2015). Peranan Trombosit Dalam Patogenesis Malaria. Majalah Kedokteran Andalas, 37(3), 219–225.
  20. Paniker, C. J. (2013). Paniker’s Textbook of Medical Parasitology. (S. Ghosh, Ed.) (7th ed.). Jaypee Brothers Medical Publishers.
  21. Promega Corporation. (2014). Go tag green master mix PCR: instruction manual, cat. no. M-7122. Madison: Promega Corporation.
  22. Provinsi Nusa Tenggara Timur Dalam Angka 2017. (2017). Badan Pusat Statistik Provinsi Nusa Tenggara Timur.
  23. Riset Kesehatan Dasar 2018. (2018). Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan Republik Indonesia.
  24. Saxena, R. (2017). Malaria: A Cause of Anemia and Its Effect on Pregnancy. World Journal of Anemia, 1, 51–62. https://doi.org/10.5005/jp-journals-10065-0012
  25. Siqueira, A. M., Cavalcante, J. A., Vítor-Silva, S., Reyes-Lecca, R. C., Alencar, A. C., Monteiro, W. M., … Bassat, Q. (2014). Influence of age on the haemoglobin concentration of malaria-infected patients in a reference centre in the Brazilian Amazon. Memórias Do Instituto Oswaldo Cruz, 109(5), 569–576.
  26. Snounou, G., Viriyakosol, S., Jarra, W., Thaithong, S., & Brown, K. N. (1993). Identification of the four human malaria parasite species in field samples by the polymerase chain reaction and detection of a high prevalence of mixed infections. Molecular and Biochemical Parasitology, 58(2), 283–292.
  27. Srivastava, A., Creek, D. J., Evans, K. J., De Souza, D., Schofield, L., Müller, S., … Waters, A. P. (2015). Host reticulocytes provide metabolic reservoirs that can be exploited by malaria parasites. PLoS Pathogens, 11(6).
  28. Srivastava, T., Negandhi, H., Neogi, S. B., Sharma, J., & Saxena, R. (2014). Methods for hemoglobin estimation: a review of “What Works.” J Hematol Transfus, 2(3), 1028.
  29. Suwandi, J. F., Asmara, W., & Kusnanto, H. (2014). Mapping and Prevalence of Malaria Falciparum Patients with ACT Failed Therapy, in Hanura Public Health Center, Pesawaran, Lampung, Indonesia. Open Journal of Epidemiology, 4(03), 169.
  30. World Health Organization. (2009). Malaria microscopy quality assurance manual: version 1. Malaria microscopy quality assurance manual: version 1. World Health Organization.
  31. World Health Organization. (2011). Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. World Health Organization.
  32. World Health Organization. (2018). World Malaria Report 2018. Geneva: World Health Organization.
  33. Yadav, K., Jacob, O. M., Ahamed, F., Mandal, M., & Kant, S. (2018). Use of Point of Care Testing (POCT) in measurement of hemoglobin. Indian Journal of Community Health, 30(Supp), 72–79.
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