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Clinical Study and Surgical Management of Alveolar Echinococcosis (AE)

Adil Mehmood, Shao Ying Mei, Zhang RuiQing, Tuerganaili Aji, Guo Qiang

First Affiliated Hospital of Xinjiang Medical University, Clinical Medical Research Center of Echinococcus and Hepatobiliary Disease of Xinjiang Uygur Autonomous Region




Background: Hepatic alveolar echinococcosis (HAE) is a serious zoonotic infection that affects humans. It may have a tumor-like appearance at times. Percutaneous treatment of HAE patients is extremely relaxing for them. HAE is a significant human zoonotic infection caused by the fox tapeworm Echinococcus Multilocularis larvae. It possesses the characteristics of an invasive tumor-like lesion due to its infiltrative growth pattern and protracted incubation period. The disease is endemic over central Europe, Asia, and North America. Objective: To determine the clinical study and Surgical management of alveolar Echinococcosis (AE). Methods: A cross-sectional study was conducted at the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, P.R China, which was performed between September 2018 and December 2023. The total number of patients in our study was 142. The number of Male patients in our study was 67 and female patients were 75. In 142 consecutive patients who underwent for blood tests and surgical Procedures. We took preoperative and postoperative blood tests for all operated patients. I take PNM staging for all patients and we took a brief history from all patients. Data was tabulated and analyzed by SPSS version 25. Results: A total of 142 patients were enrolled with a mean±SD age of 37.32±13.90. The mean±SD of Preoperative WBC was 6.85±1.76. The mean±SD of Preoperative NE was 6.85±1.76. The mean±SD of Preoperative HB was 1.33.7±23.5. The mean±SD of Preoperative Platelets was 288.21±94.1. The mean±SD of the frequency of PNM staging P1N0M0 was 21 and its percentage was 14.8. The frequency of PNM staging P2N0M0 was 59 and its percentage was 41.5. The frequency of PNM staging P3N0M0 was 29 and its percentage was 20.4. The frequency of PNM staging P4N0M0 was 33 and its percentage was 23.2. The frequency of Jaundice before surgery was 19 and its percentage was 13.4. The frequency of Laparoscopic / Laparotomy in abdominal dissection was 119 and its percentage was 83.8. The frequency of laparoscopy was 23 and its percentage was 16.2. In all cases, P-value was <0.05. Conclusion: Hepatic resection is considered safe and the only curative treatment for Hepatic alveolar echinococcosis (HAE), when the lesion can be removed completely. The advantages of this technique for AE treatment need to be compared further with the classical open approach. Laparoscopy appears as a feasible and safe approach for patients with PNM stages alveolar echinococcosis without impact on early disease recurrence. Hepatic alveolar echinococcosis will improve the treatment results by avoiding non-radical surgery associated with the development of complications after further radical surgical treatment. Liver resection remains the gold standard for AE. In our study females were more as compared to males. PNM staging of P2N0M0 patients was more in our study as compared to other stages. In our study, there was no major complication noted after the surgical procedure.



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