Correlation of HER2 Protein According to Histological Grade and Depth Invasion in Gastric Cancer

Amir Spahić

Hospital Travnik

The aim of this study was to determine the correlation of HER2 protein with histological grade and depth of invasion of the primary tumor with gastric cancer. Method: were used archival tissue samples of 60 gastric cancer patients who are treated by immunohistochemistry antibody to HER2 per the manufacturer's protocol and evaluated a modified scoring system HER2 positivity surgical resection sample obtained. Data were processed using the descriptive statistics, chi square test and one sample T-test, and Pearson's correlation test. Results: Statistical analysis of HER2 protein according to histological grade gastric adenocarcinoma made using chi-square test does not show a statistically significant correlation between these two variables (χ2 = 29.400), the analysis using one sample t-test showed no statistically significant difference (t = 2.850) and analysis with Pearson correlation test shows a positive correlation that is statistically significant (r = 0.214). Statistical analysis of the HER2 protein according to the depth of invasion of gastric cancer was performed using chi-square test does not show a statistically significant association (χ2 = 59.700), the analysis using one sample t-test showed no statistically significant difference (t = 2.900), and analysis by Pearson-this test correlation shows a positive correlation that was not statistically significant (r = 0.021). Conclusions: There is a weak positive correlation of HER2 protein according to histological grade carcinoma (r = 0.214), and was recorded negligible positive correlation of HER2 protein according to the depth of invasion of cancer (r = 0.021).

Article link: https://www.asianinstituteofresearch.org/JHMSarchives/correlation-of-her2-protein-according-to-histological-grade-and-depth-invasion-in-gastric-cancer