Potential Expression of HER2 Protein According to the Macroscopic Type of Tumor in Gastric Cancer: Original Scientific Paper
- AIOR Admin
- Jun 3
- 1 min read
Amir Spahić
Hospital Travnik, Bosnia and Herzegovina
The aim of the study was to determine the relationship between HER2 protein expression and macroscopic tumor type according to Borrmann in gastric cancer. Method: This study used archival tissue samples of gastric cancer from 60 patients obtained after subtotal or total gastrectomy with regional lymphadenectomy of lymph nodes. The most representative tissue samples of gastric cancer tissue selected by the standard hematoxylin-eosin staining method were re-cut on a microtome and immunohistochemically treated with an antibody to HER2 according to the manufacturer's protocol, and then evaluated by light microscopy and scored using a modified scoring system for HER2 positivity of surgical resections. Descriptive statistics, non-parametric significance tests, namely Chi square test and One sample T-test, as well as correlation tests, namely Pearson's correlation test, were used in data processing. Results: Statistical analysis of HER2 protein expression according to the macroscopic appearance of gastric carcinoma according to Borrmann performed using the chi-square test does not show a statistically significant relationship between these two variables (χ2=66.267), analysis using the one sample T-test does not show a statistically significant difference (t=3.080), and analysis using the Pearson correlation test shows a positive correlation that is not statistically significant (r=0.069) between these two examined parameters. Conclusion: HER2 protein expression showed a negligible positive correlation without statistical significance according to the macroscopic type of carcinoma according to Borrmann using the univariate statistical method according to Pearson.
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