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Serum Vitamin D Level and Insulin Resistance in Obese Adolescent with Polycystic Ovary Syndrome (PCOS)

Shahed Imran, Syed Shariful Islam, Shahjada Selim, Nurjahan Akter, Iffat Rubaiya Nasir, Md Mezanur Rahman, Md Kamrul Hasan Sajib

Institute of Child & Mother Health (Bangladesh), Bangabandhu Sheikh Mujib Medical University (Bangladesh), Directorate General of Health Services (Bangladesh), Khwaja Yunus Ali Medical College & Hospital (Bangladesh), Dhaka Medical College and Hospital (Bangladesh)




Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. PCOS is characterized by the presence of polycystic ovaries, menstrual dysfunction, infertility, and biochemical and clinical hyperandrogenism. The objective of this study was to evaluate the serum vitamin D Level and Insulin Resistance in Obese Adolescents with polycystic ovary syndrome (PCOS). The study was a cross-sectional study conducted among 94 PCOS women of reproductive age coming to the Department of Endocrinology & Metabolism of Bangabandhu Sheikh Mujib Medical University (BSMMU). The women with polycystic ovary syndrome were considered as the study population. Among the participants, around 91% had vitamin D deficiency and 4% had vitamin D insufficiency, no participants had a sufficiency. Among PCOS patients underweight was 42.10%, Healthy Weight 45.27%, pre-obese 9.63%, and obese 3.0%. Regarding fasting insulin levels (<20uIU/ml) among 14.9% of PCOS. In the comparison of clinical characteristics of the participants, less than half (37.2%) had painful menstruation and 67% had hirsutism. Adolescent girls with PCOS are mostly vitamin D deficient and the rate of obesity is also high. The results of this study brought the true picture of insulin resistance and metabolic syndrome among different phenotypes of women with PCOS in Bangladesh, very likely contributing to a better understanding of the management of PCOS, and patients will benefit individually in their management. Estimation of vitamin D levels & and examination the obesity may help the clinician to manage obesity cases with PCOS adolescents more efficiently.


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