Lipid Profile and Malondialdehyde (MDA) Level after Administration of Syzygium aromaticum in Sprague Dawley Rats with Dyslipidemia

Fanny Septiani Farhan, Dede Renovaldi

Universitas Muhammadiyah Jakarta, Indonesia

Dyslipidemia leads the process of oxidative stress and increased the levels of malondialdehyde (MDA). Syzygium aromaticum has an antioxidant effect and lowering lipid profile. This study aims to evaluate the changes in MDA level after administration of Syzygium aromaticum in various doses of administration. 30 male Sprague Dawley rats are divided into 6 groups: normal group (normal diet), negative control (high fat diet/HFD only), positive control (HFD and simvastatin), group 1 (HFD and Syzygium aromaticum 150mg/body weight) group 2 (HFD and Syzygium aromaticum 250mg/body weight) and group 3 (HFD and Syzygium aromaticum 500mg/body weight). The evaluation of lipid profile was performed pre and post experimental procedure (day 0 and day 42). After six weeks rats were terminazed by ketamine-xylazin injection intramuscularly, and had their liver collected for the examination of MDA levels. One-way anova test showed significant differences in lowering MDA levels in groups 2 dan 3 (HFD and Syzygium aromaticum doses 250 and 500mg/KgBB). It can be concluded that the administration of Syzygium aromaticum extract aromaticum reduced oxidative stress with MDA parameters.

Article link: https://www.asianinstituteofresearch.org/JHMSarchives/lipid-profile-and-malondialdehyde-(mda)-level-after-administration-of-syzygium-aromaticum-in-sprague-dawley-rats-with-dyslipidemia-